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. 2011 Jun 2;7(6):e1002112. doi: 10.1371/journal.pgen.1002112

Figure 7. Working model depicting role of PADI4 in Elk-1–mediated activation of c-Fos.

Figure 7

(A) Prior to stimulation, Elk-1, PADI4, and p300 constitutively occupy the c-Fos promoter. (B) Following EGF treatment, Elk-1 is citrullinated by PADI4. (C) Upon citrullination, Elk-1 is then phosphorylated by ERK2. (D) This phosphorylation event leads to an enhanced interaction between Elk-1 and p300 (9). (E) The enhanced interaction then potentiates p300-mediated histone acetylation and subsequent transcriptional activation.