Table 1. Specificities of IVIG derivatives.

IVIG & Derivatives	HSV ELISA titer	Neutralizing Titer	Sialylation Titer
IVIG or Human Serum	1/10240	1/320	+ (1/625)
HSV Adsorbed IVIG	1/5120	<1/2	+ (1/625)
*DG – IVIG	1/5120	1/320	− (<1/5)
+α2,3 DS IVIG	1/5120	1/160	− (<1/5)
+α2,6 DS IVIG	1/5120	1/320	− (<1/5)
*HSV+ S+ IgG	1/5120	<1/2	+++
*HSV+ S− IgG	1/5120	1/320	NA
HSV− Pooled Sera	<1/5	<1/2	+ (1/1250)
⋆HSV− S+ IgG	<1/5	<1/2	+++
⋆HSV− S− IgG	<1/5	<1/2	NA

*DG-IVIG, PNGase F digested IVIG to achieve deglycosylation.

+: DS-IVIG, Neuraminidase treated IVIG to remove terminal sialic acid residues at α2,3- or α2,6- position.

*^/⋆S^+/− IgG, SNA lectin column eluted IgG to separate sialylated (S⁺) or non-sialylated (S⁻) from either IVIG or HSV negative sera.

NA, not applicable.