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. 2011 Jun 2;6(6):e20301. doi: 10.1371/journal.pone.0020301

Figure 2. Effects of EGb761 (100 or 200 mg/kg) treatment or normal saline (control) on the proliferation and apoptosis of vascular smooth muscle cells.

Figure 2

A. Cell proliferation measured by immunostaining for proliferating cell nuclear antigen (PCNA) was markedly lower in the EGb761-treated groups than in the controls (open arrow). B. The proliferation index was significantly lower in the EGb761-treated groups than in the control group. There was a dose-dependent pattern in the level of proliferation between EGb761-treated groups (* p<0.05 vs. control and † p<0.05 vs. EGb100). C. TUNEL staining of the three groups (open arrow). D. Apoptosis index (%) at 3 weeks after balloon injury. Apoptosis was significantly higher in the EGb761-treated groups than in the control group, and there was a dose-dependent pattern in the level of apoptosis between EGb761-treated groups (* p<0.05 vs. control and † p<0.05 vs. EGb100).