Fig. 3.
Phylogeny of Nav channels with key amino acid sequences mapped to their corresponding taxa. Taxa are color coded the same as in Fig. 2. The amino acids are alignments of the pore loops of all four domains (DI–DIV) and the critical inactivation particle on the inactivation gate. The critical amino acids in the pore are indicated by the vertical lines, and there are red stars next to convergent lysines (red K). Note the functional conservation of the hydrophobic triplet called the “inactivation particle” (first three amino acids on the inactivation gate).