Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2011 May 12;108(22):9274–9279. doi: 10.1073/pnas.1011711108

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

PMC Copyright notice

Fig. 3. — Progressive touch neuron defects in the mec mutants. (A) Summary of the mec genes and their encoded proteins. (B) Representative live GFP images (except for that of the mec-12 mutant, which is immunofluorescence image-labeled by 6–11B-1) of the ALM processes in the wild type (D16) and the mutants (D9). (Scale bar: 5 μm.) Arrows and arrowheads indicate branching and bubble-like lesions, respectively. (C) Quantification of defective ALM processes. Total numbers of ALM neurons scored (D1/D9/D12): wild type, 29/54/70; mec-1, 25/23/20; mec-2, 17/28/19; mec-4, 24/18/31; mec-5, 31/23/22; mec-6, 19/25/27; mec-9, 20/16/27; mec-10, 23/29/20; mec-12, 19/27/25. (D) Percentages of bubble-like lesions, beading, or blebbing/branching in all of the abnormal events found in the ALM neurons of wild type and the mutants. The age of the animals is specified. (E) Defects of the ALM and the PLM processes of D3 mec-1(e1066) mutants are enhanced by a daf-16(mu86) mutation. (F) Overexpression of DAF-16 from the endogenous daf-16 promoter significantly suppresses ALM and PLM defects of D9 mec-1(e1066) mutants. Error bars are SEs of proportions. **P < 0.01 or ***P < 0.001 (Fisher's exact test or two-proportion test).