Fig. 3.

Inhibition of FGF and MAPK signaling pathways after fertilization produces different phenotypes. (A) Scheme of the pharmacological treatments performed in this study with SU5402 and U0126. Black arrows represent the time window for each continuous treatment, and red arrows represent the time points at which embryos where fixed. (B–E) Side views of embryos fixed at the early midneurula stage after treatment 1. Expression of Otx (F and F′), Nodal (G and G′), Brachyury2 (H and H′), and Neurogenin (I and I′) in early midneurula embryos after treatment 1. In the side views, anterior is to the left and dorsal is to the top.