Fig. 1.

PEGylated His₆hGH analog-induced growth in hypophysectomized rats. Six site-selective PEGylated His₆hGH analogs were compared for their ability to induce weight gain in hypophysectomized rats (N = 5–11 per group). Error bars represent standard deviation. Unless otherwise indicated, hGH, His₆hGH, and the PEGylated His₆hGH analogs were dosed once on day 0 at 2.1 mg/kg. PEGylated Y35pAcF-His₆hGH produced the largest body weight increase but was not significantly better than daily hGH administration at 0.3 mg/kg when all mean pairs were compared using a Tukey–Kramer honestly significant difference test.