Fig. 4.

Influence of magaldrate coadministration on MX PEP activity. (A) Rats were orally administered MX PEP followed by the labeled peptide with or without magaldrate. Pictures were recorded 1 and 2 h after gavage. The pictures shown are from representative rats in each set. Color scales are identical. (B, C) The graphs report the relative fluorescence signal (B) in the stomach and (C) in the small intestine with or without magaldrate treatment. Signals were plotted by setting the average in vivo maximum signal (oral administration of precleaved peptide) to 100%. Mean + SD, n = 4–9. *Precleaved peptide (p < 0.01) and **MX PEP + peptide + magaldrate (p < 0.05) vs. MX PEP + peptide and peptide alone, ***Precleaved peptide, MX PEP + peptide ± magaldrate vs. peptide alone (p < 0.05).