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Apoptotic responses to cisplatin. (a) Cells with the indicated genotypes were untreated (Control) or treated with cisplatin for 48 h. The fraction of apoptotic nuclei was assessed by fluorescence microscopy. Representative nuclei are shown at 40× magnification (inset, scale bar 10 μm). (b) Cells treated as in (a) were lysed and probed with the indicated antibodies.
