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. Author manuscript; available in PMC: 2012 Nov 15.
Published in final edited form as: Spine (Phila Pa 1976). 2011 Nov 15;36(24):E1555–E1561. doi: 10.1097/BRS.0b013e318210eec4

Figure 1. Gdf-5 and Shh expression in the intervertebral disc.

Figure 1

In situ hybridizations for Gdf-5 (left) and Shh (right). Gdf-5 is expressed in the annulus fibrosus of E14.5 embryos (red arrows) but not the notochord and nucleus pulposus (black arrows). Gdf5 is also present in the E14.5 rib joint (blue arrow). Shh is expressed in the notochord of E10.5 and E12.5 embryos and nucleus pulposus of E14.5 embryos (dark pink arrows). Shh is also present in the dorsal root ganglia (E14.5, dark blue arrow). Total magnification: 200× E10.5, 100× E12.5, E14.5.