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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Cancer Res. 2011 Apr 21;71(11):3863–3871. doi: 10.1158/0008-5472.CAN-10-4463

Figure 2. Histological analysis of thyroid tissue.

Figure 2

Control (Cre−) or Thyro::CreER (Cre+) mice carrying either a Cre-activated BRafCA or KRasLSL alleles were either untreated or treated with tamoxifen as indicated. At different times thereafter (1 week – 12 months), mice were euthanized for analysis of formaldehyde fixed, paraffin embedded (FFPE) thyroid tissue by Hematoxylin and Eosin (H&E) staining. A: Control BRafCA mice, B–G: Tamoxifen treated Thyro::CreER; BRafCA mice analyzed: 1 week (B); 2 weeks (C); 3 months (D); 6 months (E) or; 12 months (F & G) after tamoxifen treatment. H: Control KRasLSL mice. I: Thyro::CreER; KRasLSL mice analyzed 6 months after tamoxifen treatment. Magnification is 200x with the exception of G, which is 400x