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CPDT inhibits ABP-induced DNA damage, elevates Nrf2, and induces Phase 2 enzymes in bladder cells in vitro. (A) RT4 cells were treated with CPDT or solvent for 24 h and then exposed to ABP (with S9) or N-OH-AABP for 3 h, followed by dG-C8-ABP analysis by LC/MS/MS. (B) RT4 cells were treated with CPDT for 24 h. Nrf2 and Nrf2 target genes in whole cell lysates were measured by Western blotting. GAPDH is a loading control. The arrows indicate two UGT2B bands (isoforms) induced by CPDT.
