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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Cancer Res. 2011 Apr 21;71(11):3812–3821. doi: 10.1158/0008-5472.CAN-10-3072

Figure 4. Regulation of SOX9 by growth factors and injury.

Figure 4

A, SOX9 was induced in UROtsa and BFTC905 cells by treatment of EGF or HB-EGF Induction was blocked by small molecule inhibitors of ERK1/2 (U0126) or EGFR (erlotinib), but not PI3 kinase (LY294002) or p38 MAPK (PD169316). B, Immunoblots showing induction of EGFR phosphorylation and SOX9 protein levels in UROtsa cells following treatment with hydrogen peroxide or sodium chloride.