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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Cancer Res. 2011 May 24;71(11):3972–3979. doi: 10.1158/0008-5472.CAN-10-3852

Figure 5.

Figure 5

6BIO suppresses melanoma tumor growth in a mouse xenograft model. A, Toxicity study with BALB/c normal mice. 6BIO or vehicle control was administered through oral gavage once daily to each group, at doses of 50, 75 and 100 mg/kg body weight. The maximum tolerated dose (MTD) was determined as 100 mg/kg. B, 6BIO suppressed tumor growth of A2058 human melanoma xenografts in NSG mice. A2058 cells (5×106) were inoculated subcutaneously into the dorsal area of NSG mice. When tumors became palpable, 6BIO or vehicle control was administrated via oral gavage once daily. Points, mean (n = 8); bars, SE. P < 0.001.