Table 1.
Aspergillus fumigatus allergens/antigens of diagnostic relevance
| Allergen | Biological activity | Use of recombinant allergen for diagnosis |
|---|---|---|
| Asp f 1a (18 kDa) | Allergic, ribonuclease activity, cytotoxicity | IgE reactivity |
| IgG reactivity | ||
| Immunodominant peptides | ||
| Asp f2a (37 kDa) | A fibrinogen-binding protein | IgE reactivity |
| Immunodominant peptides | ||
| Asp f3a (19 kDa) | Peroxisomal membrane proteins (PMP) | IgE reactivity |
| Asp f4a (30 kDa) | Unknown biological function with | IgE reactivity |
| Immunodominant peptides | ||
| Asp f5 (42 kDa) | Metalloprotease (MEP) | IgE reactivity |
| Asp f 6a (23kD) | Manganese superoxide dismutase (MnSOD) | IgE reactivity |
| Immunodominant peptides | ||
| Asp f 8a (11.1 kDa) | A glycoprotein with homology to ribosomal protein P2 | IgE reactivity |
| Asp f 9 (18.8 kDa) | Glycosyl hydrolase | IgE reactivity |
| Asp f 10 (34.4 kDa) | Aspartic proteases (PEP) | IgE reactivity |
| Asp f 11 (95 kDa) | Cyclophilin or a dipeptidyl-peptidase IV | IgE reactivity |
| Asp f 16 (43 kDa) | A protein with unknown function and similarity to Asp f 9. | IgE reactivity |
| Immunodominant peptides | ||
| Asp f 23 (44 kDa) | Ribosomal protein L3 | IgG reactivity |
aAspergillus fumigatus allergens are used in ImmunoCap method for serodiagnosis or skin testing