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Cross-linking of CD46 to CD40 inhibits induction of Cε germ line and AID mRNA expression in B cells by CD40 and IL-4. Purified human B cells were incubated with the indicated stimuli and GAMIG. Four days later, mRNA was extracted and analyzed by RT–PCR for the presence of Cε germ line and AID mRNA. GAPDH mRNA was used as loading control. Similar results were obtained in two other experiments.
