Table 3.
Predictors of hospitalization among infants born to HIV-infected mothers within the first 100 days of life (N = 813)
| Univariate analysis |
Multivariable analysis |
|||
|---|---|---|---|---|
| Category | Hazard ratio (HR) (95% CI) | p-value | Hazard ratio (HR) (95% CI) | p-value |
| Maternal correlates | ||||
| Maternal age | ||||
| ≤20 | 0.34 (0.13–0.92) | 0.034 | 0.25 (0.07–0.88) | 0.031 |
| 20–25 | 0.47 (0.26–0.95) | 0.034 | 0.51 (0.24–1.07) | 0.075 |
| 25–30 | 0.79 (0.41–1.51) | 0.473 | 0.79 (0.40–1.57) | 0.502 |
| >30 | 1.00 | – | 1.00 | – |
| Maternal CD4 cell count | ||||
| ≤350 cells µl−1 | 1.82 (1.06–3.15) | 0.031 | 1.27 (0.70–2.28) | 0.427 |
| >350 cells µl−1 | 1.00 | – | 1.00 | – |
| Maternal PVL | ||||
| >100 000 copies ml−1 | 2.39 (1.38–4.13) | 0.002 | 1.87 (1.01–3.48) | 0.048 |
| ≤100 000 copies ml−1 | 1.00 | – | 1.00 | – |
| Maternal death | ||||
| Yes | 1.63 (0.40–6.69) | 0.50 | 0.40 (0.05–3.07) | 0.380 |
| No | 1.00 | – | 1.00 | – |
| Infant correlates | ||||
| Infant prophylaxis status | ||||
| Zidovudine | 1.15 (0.68–1.93) | 0.604 | 0.92 (0.53–1.62) | 0.782 |
| Nevirapine | 1.00 | – | 1.00 | – |
| Infant HIV status | ||||
| HIV infected | 3.43 (2.00–5.88) | <0.0001 | 2.61 (1.40–4.85) | 0.002 |
| HIV uninfected | 1.00 | 1.00 | – | |
| Infant birth weight | ||||
| ≤2500 g | 1.24 (0.67–2.30) | 0.496 | 1.05 (0.55–2.02) | 0.879 |
| >2500 g | 1.00 | – | 1.00 | – |
| Infant feeding methoda | ||||
| Formula feeding | 1.02 (0.98–1.06) | 0.33 | 1.03 (0.99–1.07) | 0.102 |
| Breast milk | 1.00 | – | 1.00 | – |
aInfant-feeding method was analyzed as a time-dependent covariate in the multivariable analysis.