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. Author manuscript; available in PMC: 2011 Jun 3.
Published in final edited form as: Behav Genet. 2010 Jan 29;40(2):262–279. doi: 10.1007/s10519-010-9335-3

Fig. 1.

Fig. 1

Flow diagram of presynaptic control elements in the serotonin system. Dietary tryptophan is converted to serotonin by TPH2 and stored in the intracellular compartment. Serotonin is released into the synapse as a function of a refractory period and input from two autoreceptors that inhibit firing (5-HT1A) or influence the amount of serotonin released (5-HT1B). Serotonin is removed from the synaptic space by the serotonin transporter (SERT) via reuptake. Serotonin is either repackaged for re-release or it is catabolized by MAOA and its by product 5-HIAA is transported to the cerebral spinal fluid