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Models of 5-HT and DA transport by the hSERT. A simplified drawing of state diagrams summarizing the basic features and favored equilibria of 5-HT (left) and DA (right) transport by SERT. Only chloride ion, sodium ion, and substrate is shown. The star shape denotes the accessibility of the reactive cysteine (Q332C) to MTSET modification. Below each diagram is a drawing of the transporter itself illustrating subunit–subunit interactions.
