Figure 2.

Selective OP deficit in KO mice. A, In the MWM, there were no significant differences in the average time to locate the hidden platform, plotted for each day animals were tested. Inset, There were no differences between genotypes in the probe trial (1, 2, 3, and 4 reflect each quadrant; 4 = target quadrant; see Notes). Note that CD1 mice normally do not exhibit a preference for the target quadrant in the probe trial (Adams et al., 2002). B, In CFC, there were no significant differences between WT and KO mice in the conditioning or testing trials. C, KO mice were impaired in OP because they did not spend more time in trial 2 exploring the moved object, but WT mice did.