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. 2011 Jan 19;103(2):105–116. doi: 10.1093/jnci/djq494

Figure 1.

Figure 1

Forest plots of study-specific associations between the single-nucleotide polymorphism (SNP) rs3814113 and ovarian cancer risk among BRCA1 or BRCA2 mutation carriers. Study-specific per-allele hazard ratio estimates are presented. A) BRCA1 mutation carriers. B) BRCA2 mutation carriers. The area of the square is proportional to the inverse of the variance of the estimate. Horizontal lines = 95% confidence intervals; diamonds = the summary for all of Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Some of the smaller studies of BRCA2 mutation carriers have been combined with other studies from the same country. Study names are as follows: BCFR = Breast Cancer Family Registry; BFBOCC = Baltic Familial Breast and Ovarian Cancer Consortium; CBCS = Copenhagen Breast Cancer Study; CNIO = Spanish National Cancer Centre; CONSIT TEAM = CONsorzio Studi ITaliani sui Tumori Ereditari Alla Mammella; DKFZ = Deutsches Krebsforschungszentrum; DNA HEBON = HEreditary Breast and Ovarian study Netherlands; EMBRACE = Epidemiological Study of BRCA1 and BRCA2 Mutation Carriers; FCCC = Fox Chase Cancer Center; GC-HBCO = German Consortium of Hereditary Breast and Ovarian Cancer; GEMO = Genetic Modifiers of Cancer Risk in BRCA1/2 Mutation Carriers; HCSC = Hospital Clinico San Carlos; HEBCS = Helsinki Breast Cancer Study; ICO = Institut Català d’Oncologia; IHCC = International Hereditary Cancer Centre; ILUH = Iceland Landspitali—University Hospital; INHERIT = Interdisciplinary Health Research International Team Breast Cancer Susceptibility; IOVHBOCS = Istituto Oncologico Veneto Hereditary Breast and Ovarian Cancer Study; KCONFAB = Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer; MAYO = Mayo Clinic; MSKCC = Memorial Sloane Kettering Cancer Center; NCI = National Cancer Institute; NNPIO = N. N. Petrov Institute of Oncology; OCGN = Ontario Cancer Genetics Network; OUH = Odense University Hospital; PBCS = Pisa Breast Cancer Study; SWE-BRCA = Swedish Breast Cancer Study; UCI = University of California Irvine; UCSF = University of California San Francisco; UKGRFOCR = UK and Gilda Radner Familial Ovarian Cancer Registries; UPENN = University of Pennsylvania; WCRI = Women’s Cancer Research Institute.