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Comparison of Cell Doses and Outcome with Lentiviral Vectors, hPGK-cCD18, or MSCV-cCD18 Transduced CD34+ Cells Infused into CLAD Dogs
| Dog | Infused CD34+cells/kg | % CD18+ | Transduced cells/kg infused | Outcome (weeks) |
|---|---|---|---|---|
| PGK1 | 10.5 × 106 | 16.5 | 1.7 × 106 | Death (10) |
| PGK2 | 8.6 × 106 | 12.0 | 1.0 × 106 | Death (9.4) |
| PGK3 | 11.0 × 106 | 5.1 | 0.6 × 106 | Death (10.6) |
| PGK4 | 5.4 × 106 | 14.0 | 0.8 × 106 | Alive (52) |
| MSCV1 | 12.3 × 106 | 10.3 | 1.3 × 106 | Alive (52) |
| MSCV2 | 13.0 × 106 | 6.0 | 0.8 × 106 | Alive (52) |
