Table 5.
Ratios of Damaging to Benign Polymorphisms in Humans and Chimpanzees for Different Subclasses of TLRs.
| Probably Damaging | Possibly Damaging | Benign | Pa | Pb | |
| Human genomec | 11,174 | 14,187 | 49,795 | — | |
| All human TLRs | 11 | 20 | 31 | 0.02 | <0.001 |
| Human viral TLRs | 0 | 5 | 8 | 0.08 | 0.8 |
| Human nonviral TLRs | 11 | 15 | 23 | 0.02 | 0.005 |
| All chimpanzee TLRs | 3 | 3 | 19 | 0.58 (0.07)d | 0.4 (0.03)d |
| Chimpanzee viral TLRs | 0 | 1 | 6 | 0.47 | 0.4 |
| Chimpanzee nonviral TLRs | 3 | 2 | 13 | 0.74 | 0.6 |
a
Compared with the human genome.
b
Compared with the human genome, collapsing the probably and possibly damaging mutations.
c
From Sunyaev et al. (2001).
d
Comparison with all human TLRs in parentheses.