Table 6.

dN/dS Values for the Human Lineage, the Chimpanzee Lineage, and across Primates.

	Human Brancha	Chimpanzee Brancha	Primatesb
			Global	SP	EXT	TM	CYT
TLR1	1.04	1.35	0.43	0.59	0.45	0.33	0.21
TLR2	n/ac	0.31	0.44	0.40	0.52	0.21	0.13
TLR3	0.20	0.64	0.32	0.87	0.30	n/ac	0.23
TLR4	0.20	1.39	0.57	0.48	0.71	2.35	0.17
TLR5	0.80	0.54	0.42	1.04	0.43	0.46	0.32
TLR6	0.33	0.59	0.40	0.62	0.38	0.57	0.28
TLR7	0.29	0.60	0.34	1.33	0.36	1.37	0.10
TLR8	0.12	0.06	0.39	0.78	0.44	0.45	0.10
TLR9	0.22	0.15	0.17	0.23	0.17	0.40	0.11
TLR10	0.18	0.26	0.48	0.36	0.46	0.46	0.52
Viral average	0.21	0.36	0.31	0.80	0.32	0.74	0.13
Nonviral average	0.51	0.74	0.46	0.58	0.49	0.73	0.27
Pd	0.09	0.10	0.007	0.17	0.02	0.49	0.05

n/a, not applicable.

SP, signal peptide; EXT, extracellular domain; TM, transmembrane domain; CYT, cytoplasmic domain.

^aMacaque sequence used to polarize changes along the human or chimpanzee branches.

^bAverage dN/dS across primates.

^cdS = 0.

^dViral and nonviral averages were compared with a t test.