Table 1. Intracellular accumulation of 14C-FIAU and 3H-FAU in HSV-tk expressing and control MH3924A cells grown in culture.
MH3924A | MH3924A-stb-tk+ | Selectivity index | P value | |
---|---|---|---|---|
% of incubated dose/105 cells | ||||
FIAU | 0.285 | 7.261 | 25.5 | <0.0001 |
FAU | 0.002 | 0.075 | 34.5 | <0.0001 |