Table 2. Vx ion channel block use-dependence.
Channel | BCL (s) |
Vx (nM) |
Increase (Δ%) |
---|---|---|---|
ICa,L | 1 | 30 | 11±1 (3) |
1 | 100 | 23±19 (2) | |
1 | 300 | 83±10 (2)* | |
0.3 | 30 | 10±7 (2) | |
0.3 | 100 | 60±13 (2)* | |
| |||
hNav1.5 | 3 | 300 | 5±5 (2) |
0.3 | 300 | 70±11 (2)* | |
| |||
hKv11.1 | 3 | 10 | 3±3 (3) |
0.3 | 10 | 30±8 (3)* |
Statistically significant change from control (P<0.05) using ANOVA and Dunnett's multiple comparison test.