Table 3. Vx modulation of canine Purkinje fiber AP parameters a.
| Vx (μM) |
BCL (s) |
APD60 (Δ%) |
APD90 (Δ%) |
RMP (ΔmV) |
APA (ΔmV) |
|---|---|---|---|---|---|
| 0.5 | 2.7±1.6 | 1.8±1.9 | 0.1±3.7 | 5.9±6.2 | |
| 0.01 | 1 | 4.3±0.8 | 3.6±1.6 | 0.6±3.9 | 6.3±6.5 |
| 2 | 7.5±1.9 | 7.0±2.7 | 0.4±3.8 | 6.7±6.5 | |
| 0.5 | 1.8±3.3 | 4.9±1.8 | 2.0±5.0 | -3.1±14.6 | |
| 0.1 | 1 | 2.7±2.9 | 10.1±2.5 | 2.5±5.9 | -2.7±15.0 |
| 2 | 2.7±3.9 | 0.1±6.1 | 3.9±6.4 | -1.0±13.4 | |
| 0.5 | -5.3±5.8 | 2.1±3.2 | -0.4±2.7 | 4.3±8.5 | |
| 1 | 1 | -5.0±7.0 | 2.6±4.5 | -0.1±3.2 | 5.5±8.3 |
| 2 | -4.6±8.1 | 2.7±5.5 | 0.7±3.3 | 3.8±7.0 |
a
Data were obtained from 3 canine Purkinje fibers. Basic cycle length (BCL); action potential duration at 60% repolarization (APD60) and at 90% repolarization (APD90); resting membrane potential (RMP); action potential amplitude (APA).
*
No statistically significant changes from control (P<0.05) were observed using ANOVA and Dunnett's multiple comparison test.