Table 4. Vx, dofetilide and amiodarone modulation of APD90 in the canine left ventricular wedge a.
| APD90 | Epicardial | Midmyocardial | Endocardial | ||||||
|---|---|---|---|---|---|---|---|---|---|
| BCL(s) | 0.5 | 1 | 2 | 0.5 | 1 | 2 | 0.5 | 1 | 2 |
| Vx (μM) | Δ% | Δ% | Δ% | Δ% | Δ% | Δ% | Δ% | Δ% | Δ% |
| 0.01 | -0.1 ± 0.7 (7) | 1.1 ± 0.7 (7) | 1.4 ± 0.6 (7) | 1.2 ± 1.0 (7) | 1.6 ± 0.4 (7) | 0.6 ± 0.8 (7) | 0.7 ± 0.5 (7) | 2.6 ± 0.9 (7) | 2.0 ± 1.5 (7) |
| 0.03 | 0.0 ± 0.8 (8) | 1.1 ± 0.8 (8) | 2.8 ± 0.8 (8) | 1.3 ± 0.7 (8) | 2.2 ± 0.5 (8) | 1.5 ± 0.8 (8) | 0.9 ± 0.8 (8) | 3.3 ± 0.8 (8) | 2.8 ± 1.2 (8) |
| 0.1 | 0.5 ± 1.1 (8) | 2.0 ± 1.3 (8) | 3.5 ± 0.5 (8) | 2.3 ± 1.2 (8) | 3.5 ± 0.5 (8) | 2.8 ± 1.3 (8) | -0.7 ± 1.4 (8) | 4.2 ± 0.6 (8) | 4.5 ± 1.9 (8) |
| 0.3 | 2.1 ± 0.9 (8) | 3.4 ± 1.2 (8) | 4.2 ± 0.8 (8) | 4.0 ± 0.7 (8) | 5.5 ± 1.0 (8) | 5.6 ± 1.2 (8) | 0.4 ± 2.0 (8) | 5.2 ± 0.9 (8) | 6.9 ± 1.4 (8) |
| 1 | 4.2 ± 1.2 (8) | 4.8 ± 1.0 (8) | 5.6 ± 0.8 (8) | 4.4 ± 0.7 (8) | 7.0 ± 0.9 (8)* | 7.4 ± 1.1 (8) | 3.4 ± 0.6 (8) | 6.4 ± 0.7 (8) | 8.7 ± 1.0 (8) |
| 3 | 6.1 ± 1.8 (5)* | 6.0 ± 1.2 (5) | 5.1 ± 0.7 (5) | 6.0 ± 0.9 (5) | 6.9 ± 1.0 (5) | 7.8 ± 1.3 (5) | 4.8 ± 0.6 (5) | 6.8 ± 0.7 (5) | 9.8 ± 1.2 (5) |
| Dof (μM) | Δ% | Δ% | Δ% | Δ% | Δ% | Δ% | Δ% | Δ% | Δ% |
| 0.01 | 11.7 ± 2.1 (6)* | 8.9 ± 1.3 (6)* | 7.4 ± 0.9 (6) | 10.9 ± 1.9 (6)* | 10.5 ± 1.8 (6)* | 8.8 ± 1.3 (6) | 11.9 ± 1.5 (6) | 10.5 ± 2.0 (6) | 10.7 ± 2.3 (6) |
| 0.03 | 14.7 ± 1.4 (6)* | 13.5 ± 1.8 (6)* | 15.4 ± 1.3 (6)* | 13.4 ± 2.0 (6)* | 15.0 ± 1.3 (6)* | 17.3 ± 1.4 (6)* | 13.3 ± 2.9 (6)* | 16.1 ± 3.7 (6) | 18.3 ± 1.4 (6)* |
| 0.1 | 17.8 ± 2.0 (6)* | 17.8 ± 1.7 (6)* | 18.3 ± 1.6 (6)* | 17.6 ± 2.6 (6)* | 20.7 ± 1.8 (6)* | 22.5 ± 1.8 (6)* | 15.3 ± 2.4 (6)* | 20.6 ± 3.5 (6)* | 23.4 ± 1.6 (6)* |
| 0.3 | 19.0 ± 2.0 (6)* | 20.2 ± 2.0 (6)* | 20.7 ± 1.8 (6)* | 21.5 ± 2.6 (6)* | 22.3 ± 1.8 (6)* | 24.7 ± 1.3 (6)* | 18.1 ± 3.0 (6)* | 23.2 ± 2.9 (6)* | 26.2 ± 2.4 (6)* |
| 1 | 19.9 ± 1.9 (6)* | 23.3 ± 1.9 (6)* | 23.4 ± 1.5 (6)* | 21.6 ± 2.8 (6)* | 25.1 ± 2.1 (6)* | 29.5 ± 1.9 (6)* | 19.8 ± 1.6 (6)* | 24.9 ± 3.2 (6)* | 27.0 ± 2.7 (6)* |
| Amio (μM) | Δ% | Δ% | Δ% | Δ% | Δ% | Δ% | Δ% | Δ% | Δ% |
| 0.01 | 1.2 ± 0.5 (4) | 2.0 ± 0.8 (4) | 1.8 ± 0.5 (4) | 0.7 ± 0.3 (4) | 0.8 ± 0.3 (4) | 1.0 ± 0.9 (4) | 0.0 ± 1.0 (4) | 1.7 ± 0.8 (4) | 0.7 ± 0.8 (4) |
| 0.03 | 3.1 ± 0.7 (4) | 3.1 ± 1.4 (4) | 2.0 ± 0.4 (4) | 0.1 ± 0.8 (4) | 2.1 ± 0.5 (4) | 1.9 ± 0.5 (4) | -0.2 ± 0.8 (4) | 2.4 ± 1.2 (4) | 2.6 ± 1.0 (4) |
| 0.1 | 1.2 ± 0.5 (4) | 1.4 ± 0.6 (4) | 2.7 ± 1.3 (4) | 0.9 ± 1.0 (4) | 1.9 ± 0.3 (4) | 1.8 ± 0.7 (4) | -1.3 ± 1.5 (4) | 1.1 ± 1.0 (4) | 2.2 ± 0.6 (4) |
| 0.3 | -2.1 ± 1.3 (4) | -0.7 ± 1.4 (4) | 0.7 ± 1.4 (4) | -2.8 ± 2.3 (4) | -2.6 ± 1.1 (4) | -2.1 ± 1.2 (4) | -4.7 ± 2.6 (4) | -3.1 ± 3.7 (4) | -0.9 ± 1.3 (4) |
| 1 | -2.3 ± 2.3 (4) | -3.2 ± 2.7 (4) | -2.8 ± 1.9 (4) | -7.1 ± 4.1 (4) | -5.5 ± 2.3 (4) | -3.1 ± 1.6 (4) | -5.8 ± 3.5 (4) | -4.6 ± 4.1 (4) | -2.8 ± 1.2 (4) |
| 3 | -3.9 ± 2.6 (4) | -5.3 ± 3.8 (4) | -4.2 ± 3.1 (4) | -4.6 ± 3.7 (4) | -4.9 ± 1.8 (4) | -4.2 ± 2.1 (4) | -9.1 ± 4.8 (4) | -9.4 ± 5.4 (4) | -4.3 ± 1.2 (4) |
| 10 | -6.4 ± 2.0 (4)* | -8.9 ± 2.5 (4)* | -10.8 ± 5.2 (4)* | -36.0 ± 21.4 (4)* | -13.1 ± 4.3 (4)* | -12.0 ± 4.9 (4)* | -9.7 ± 4.4 (4) | -14.2 ± 3.9 (4) | -10.6 ± 4.0 (4)* |
*
Statistically significant change from control (P<0.05) using ANOVA and Dunnett's multiple comparison test.
a
Data are shown as mean ± SEM (n). Vanoxerine (Vx); dofetilide (Dof); amiodarone (Amio).