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. Author manuscript; available in PMC: 2011 Jun 3.
Published in final edited form as: J Cardiovasc Electrophysiol. 2009 Oct 8;21(3):301–310. doi: 10.1111/j.1540-8167.2009.01623.x

Table 4. Vx, dofetilide and amiodarone modulation of APD90 in the canine left ventricular wedge a.

APD90 Epicardial Midmyocardial Endocardial
BCL(s) 0.5 1 2 0.5 1 2 0.5 1 2
Vx (μM) Δ% Δ% Δ% Δ% Δ% Δ% Δ% Δ% Δ%
0.01 -0.1 ± 0.7 (7) 1.1 ± 0.7 (7) 1.4 ± 0.6 (7) 1.2 ± 1.0 (7) 1.6 ± 0.4 (7) 0.6 ± 0.8 (7) 0.7 ± 0.5 (7) 2.6 ± 0.9 (7) 2.0 ± 1.5 (7)
0.03 0.0 ± 0.8 (8) 1.1 ± 0.8 (8) 2.8 ± 0.8 (8) 1.3 ± 0.7 (8) 2.2 ± 0.5 (8) 1.5 ± 0.8 (8) 0.9 ± 0.8 (8) 3.3 ± 0.8 (8) 2.8 ± 1.2 (8)
0.1 0.5 ± 1.1 (8) 2.0 ± 1.3 (8) 3.5 ± 0.5 (8) 2.3 ± 1.2 (8) 3.5 ± 0.5 (8) 2.8 ± 1.3 (8) -0.7 ± 1.4 (8) 4.2 ± 0.6 (8) 4.5 ± 1.9 (8)
0.3 2.1 ± 0.9 (8) 3.4 ± 1.2 (8) 4.2 ± 0.8 (8) 4.0 ± 0.7 (8) 5.5 ± 1.0 (8) 5.6 ± 1.2 (8) 0.4 ± 2.0 (8) 5.2 ± 0.9 (8) 6.9 ± 1.4 (8)
1 4.2 ± 1.2 (8) 4.8 ± 1.0 (8) 5.6 ± 0.8 (8) 4.4 ± 0.7 (8) 7.0 ± 0.9 (8)* 7.4 ± 1.1 (8) 3.4 ± 0.6 (8) 6.4 ± 0.7 (8) 8.7 ± 1.0 (8)
3 6.1 ± 1.8 (5)* 6.0 ± 1.2 (5) 5.1 ± 0.7 (5) 6.0 ± 0.9 (5) 6.9 ± 1.0 (5) 7.8 ± 1.3 (5) 4.8 ± 0.6 (5) 6.8 ± 0.7 (5) 9.8 ± 1.2 (5)
Dof (μM) Δ% Δ% Δ% Δ% Δ% Δ% Δ% Δ% Δ%
0.01 11.7 ± 2.1 (6)* 8.9 ± 1.3 (6)* 7.4 ± 0.9 (6) 10.9 ± 1.9 (6)* 10.5 ± 1.8 (6)* 8.8 ± 1.3 (6) 11.9 ± 1.5 (6) 10.5 ± 2.0 (6) 10.7 ± 2.3 (6)
0.03 14.7 ± 1.4 (6)* 13.5 ± 1.8 (6)* 15.4 ± 1.3 (6)* 13.4 ± 2.0 (6)* 15.0 ± 1.3 (6)* 17.3 ± 1.4 (6)* 13.3 ± 2.9 (6)* 16.1 ± 3.7 (6) 18.3 ± 1.4 (6)*
0.1 17.8 ± 2.0 (6)* 17.8 ± 1.7 (6)* 18.3 ± 1.6 (6)* 17.6 ± 2.6 (6)* 20.7 ± 1.8 (6)* 22.5 ± 1.8 (6)* 15.3 ± 2.4 (6)* 20.6 ± 3.5 (6)* 23.4 ± 1.6 (6)*
0.3 19.0 ± 2.0 (6)* 20.2 ± 2.0 (6)* 20.7 ± 1.8 (6)* 21.5 ± 2.6 (6)* 22.3 ± 1.8 (6)* 24.7 ± 1.3 (6)* 18.1 ± 3.0 (6)* 23.2 ± 2.9 (6)* 26.2 ± 2.4 (6)*
1 19.9 ± 1.9 (6)* 23.3 ± 1.9 (6)* 23.4 ± 1.5 (6)* 21.6 ± 2.8 (6)* 25.1 ± 2.1 (6)* 29.5 ± 1.9 (6)* 19.8 ± 1.6 (6)* 24.9 ± 3.2 (6)* 27.0 ± 2.7 (6)*
Amio (μM) Δ% Δ% Δ% Δ% Δ% Δ% Δ% Δ% Δ%
0.01 1.2 ± 0.5 (4) 2.0 ± 0.8 (4) 1.8 ± 0.5 (4) 0.7 ± 0.3 (4) 0.8 ± 0.3 (4) 1.0 ± 0.9 (4) 0.0 ± 1.0 (4) 1.7 ± 0.8 (4) 0.7 ± 0.8 (4)
0.03 3.1 ± 0.7 (4) 3.1 ± 1.4 (4) 2.0 ± 0.4 (4) 0.1 ± 0.8 (4) 2.1 ± 0.5 (4) 1.9 ± 0.5 (4) -0.2 ± 0.8 (4) 2.4 ± 1.2 (4) 2.6 ± 1.0 (4)
0.1 1.2 ± 0.5 (4) 1.4 ± 0.6 (4) 2.7 ± 1.3 (4) 0.9 ± 1.0 (4) 1.9 ± 0.3 (4) 1.8 ± 0.7 (4) -1.3 ± 1.5 (4) 1.1 ± 1.0 (4) 2.2 ± 0.6 (4)
0.3 -2.1 ± 1.3 (4) -0.7 ± 1.4 (4) 0.7 ± 1.4 (4) -2.8 ± 2.3 (4) -2.6 ± 1.1 (4) -2.1 ± 1.2 (4) -4.7 ± 2.6 (4) -3.1 ± 3.7 (4) -0.9 ± 1.3 (4)
1 -2.3 ± 2.3 (4) -3.2 ± 2.7 (4) -2.8 ± 1.9 (4) -7.1 ± 4.1 (4) -5.5 ± 2.3 (4) -3.1 ± 1.6 (4) -5.8 ± 3.5 (4) -4.6 ± 4.1 (4) -2.8 ± 1.2 (4)
3 -3.9 ± 2.6 (4) -5.3 ± 3.8 (4) -4.2 ± 3.1 (4) -4.6 ± 3.7 (4) -4.9 ± 1.8 (4) -4.2 ± 2.1 (4) -9.1 ± 4.8 (4) -9.4 ± 5.4 (4) -4.3 ± 1.2 (4)
10 -6.4 ± 2.0 (4)* -8.9 ± 2.5 (4)* -10.8 ± 5.2 (4)* -36.0 ± 21.4 (4)* -13.1 ± 4.3 (4)* -12.0 ± 4.9 (4)* -9.7 ± 4.4 (4) -14.2 ± 3.9 (4) -10.6 ± 4.0 (4)*
*

Statistically significant change from control (P<0.05) using ANOVA and Dunnett's multiple comparison test.

a

Data are shown as mean ± SEM (n). Vanoxerine (Vx); dofetilide (Dof); amiodarone (Amio).