Table 5. Vx, dofetilide and amiodarone modulation of the QT and TDR intervals in the canine left ventricular wedge a.
| QT | TDR | |||||
|---|---|---|---|---|---|---|
| BCL(s) | 0.5 | 1 | 2 | 0.5 | 1 | 2 |
| Vx (μM) | Δ% | Δ% | Δ% | Δ% | Δ% | Δ% |
| 0.01 | 0.7 ± 1.0 (6) | 1.5 ± 1.4 (8) | 0.8 ± 0.7 (8) | 3.2 ± 13.2 (6) | 1.6 ± 5.9 (7) | 1.7 ± 3.2 (8) |
| 0.03 | 2.4 ± 2.1 (7) | 1.9 ± 1.8 (8) | 1.3 ± 1.1 (8) | -3.3 ± 16.6 (7) | 1.6 ± 5.2 (8) | 4.5 ± 3.5 (8) |
| 0.1 | 3.0 ± 0.6 (7) | 2.3 ± 1.6 (8) | 2.8 ± 1.2 (8) | 16.1 ± 16.6 (7) | 3.0 ± 5.8 (8) | 10.0 ± 4.4 (8) |
| 0.3 | 4.8 ± 1.1 (8) | 4.5 ± 1.5 (8) | 5.0 ± 0.8 (8) | 9.2 ± 18.2 (8) | 4.4 ± 6.4 (8) | 12.4 ± 3.3 (8) |
| 1 | 3.6 ± 1.9 (7) | 6.5 ± 0.9 (8) | 7.3 ± 0.7 (8) | 6.8 ± 18.2 (8) | 5.5 ± 6.3 (8) | 18.5 ± 3.2 (8) |
| 3 | 4.1 ± 7.1 (2) | 6.8 ± 1.1 (5) | 6.7 ± 0.5 (5) | 8.7 ± 31.3 (5) | 7.0 ± 6.9 (5) | 15.8 ± 4.3 (5) |
| Dof (μM) | Δ% | Δ% | Δ% | Δ% | Δ% | Δ% |
| 0.01 | 9.2 ± 1.0 (6)* | 10.5 ± 1.0 (6)* | 9.2 ± 1.2 (6)* | 20.4 ± 9.3 (6) | 9.9 ± 14.6 (6) | 8.8 ± 4.7 (6) |
| 0.03 | 11.5 ± 0.9 (6)* | 15.0 ± 1.2 (6)* | 15.4 ± 1.8 (6)* | 14.7 ± 11.6 (6) | 17.0 ± 17.2 (6) | 12.5 ± 4.7 (6) |
| 0.1 | 16.4 ± 1.2 (6)* | 20.5 ± 1.4 (6)* | 20.3 ± 1.8 (6)* | 32.2 ± 19.2 (6) | 27.4 ± 18.9 (6) | 23.3 ± 6.4 (6) |
| 0.3 | 16.8 ± 1.2 (6)* | 22.4 ± 0.6 (6)* | 22.9 ± 1.8 (6)* | 19.8 ± 15.7 (6) | 30.7 ± 13.2 (6) | 28.1 ± 3.1 (6) |
| 1 | 18.2 ± 1.9 (6)* | 24.8 ± 1.1 (6)* | 28.0 ± 1.8 (6)* | 19.9 ± 11.7 (6) | 41.0 ± 14.1 (6)* | 44.3 ± 2.6 (6)* |
| Amio (μM) | Δ% | Δ% | Δ% | Δ% | Δ% | Δ% |
| 0.01 | 1.1 ± 0.8 (4) | 0.3 ± 0.2 (4) | 1.6 ± 0.8 (4) | 3.4 ± 2.6 (4) | 1.3 ± 1.0 (4) | 5.5 ± 2.8 (4) |
| 0.03 | 1.5 ± 1.1 (4) | 1.6 ± 0.5 (4) | 2.3 ± 0.8 (4) | 4.6 ± 5.6 (4) | 5.3 ± 4.5 (4) | 10.8 ± 2.2 (4) |
| 0.1 | -0.5 ± 1.6 (4) | 0.4 ± 0.6 (4) | 1.8 ± 1.0 (4) | -1.6 ± 8.1 (4) | 0.5 ± 6.4 (4) | 7.5 ± 1.6 (4) |
| 0.3 | -1.1 ± 0.8 (4) | -2.6 ± 1.1 (4) | -2.2 ± 1.3 (4) | -3.1 ± 8.6 (4) | -13.3 ± 11.3 (4) | 0.3 ± 5.9 (4) |
| 1 | -2.7 ± 1.1 (4) | -4.5 ± 1.8 (4) | -3.9 ± 2.2 (4) | -1.0 ± 12.3 (4) | -12.9 ± 11.4 (4) | -4.1 ± 7.8 (4) |
| 3 | -2.3 ± 1.9 (4) | -6.9 ± 1.5 (4)* | -5.6 ± 2.4 (4) | 0.7 ± 18.7 (4) | -28.7 ± 10.6 (4) | -8.4 ± 5.4 (4) |
| 10 | -6.8 ± 2.1 (2) | -13.5 ± 0.3 (3)* | -10.3 ± 2.9 (4)* | -21.3 ± 44.4 (2) | -31.2 ± 11.7 (3) | -14.0 ± 8.4 (4) |
*
Statistically significant change from control (P<0.05) using ANOVA and Dunnett's multiple comparison test.
a
Data are shown as mean ± SEM (n). Vanoxerine (Vx); dofetilide (Dof); amiodarone (Amio).