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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Helicobacter. 2011 Jun;16(3):169–178. doi: 10.1111/j.1523-5378.2011.00839.x

Figure 1. Protective immunity against H. pylori in IL-17A KO mice.

Figure 1

WT and IL-17A KO mice were intranasally immunized once a week for four weeks with 100 µg of H. pylori sonicate plus 5 µg of cholera toxin. On days 7 and 8 post-immunization, mice were challenged by orogastric gavage with 1–2 × 107 cfu live H. pylori. Two additional groups of I/C mice were inoculated i.p. with 1 mg of either control rat IgG or anti-IFNγ monoclonal Ab 1 day prior to and 1 week following the first bacterial challenge. Naive mice were untreated. Gastric biopsies were harvested from all mice two weeks post-challenge and evaluated for gastritis (A), H. pylori load (B) and gastric neutrophil numbers (C). Similar results were obtained in two experiments. n = 5 – 8 mice/group. N.S. = not significant.