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. 1998 Sep;8(9):967–974. doi: 10.1101/gr.8.9.967

Table 1.

Comparison of Running Times and Accuracy of Programs That Align Spliced Sequences to their Genomic Counterparts

Time (sec)/seq. Errors per alignment



0 1–10 11–20 21–35




est2gen 156
est_genome 20 143 21 13 7
sim4, N = 0 0.06 166 11 6 1
sim4, N = 1 0.06 172 6 5 1

Running times are the average time per sequence in the 184-sequence Drosophila test set. Errors were scored as described in Validating sim4’s Alignments. As discussed in Comparisons with Similar Tools, est2gen results could not be scored but were less accurate than est_genome or sim4.