Table 3.
Associations Between 10-Year Acetaminophen, Aspirin, and Nonaspirin NSAID Use and Risk of Hematologic Malignancies
| Use in 10 Years Prior to Baseline* | Cases(n = 577) |
Noncases(n = 64,262) |
Adjusted for Age and Sex |
Multivariable Adjusted† |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. | % | No. | % | HR | 95% CI | P | P Trend | HR | 95 CI | P | P Trend | |
| Acetaminophen | < .001 | .004 | ||||||||||
| Nonuser | 405 | 73.2 | 48,523 | 77.9 | Ref.‡ | Ref.‡ | ||||||
| Low | 96 | 17.4 | 10,552 | 16.9 | 1.22 | 0.97 to 1.52 | .086 | 1.16 | 0.92 to 1.47 | .201 | ||
| High | 52 | 9.4 | 3,206 | 5.2 | 2.04 | 1.53 to 2.72 | < .001 | 1.84 | 1.35 to 2.50 | < .001 | ||
| Low-dose aspirin | .759 | .840 | ||||||||||
| Nonuser | 371 | 68.0 | 43,717 | 71.8 | Ref.‡ | Ref.‡ | ||||||
| Low | 89 | 16.3 | 9,895 | 16.3 | 0.97 | 0.77 to 1.22 | .791 | 0.97 | 0.77 to 1.23 | .795 | ||
| High | 86 | 15.8 | 7,270 | 11.9 | 1.05 | 0.83 to 1.34 | .664 | 1.04 | 0.82 to 1.33 | .739 | ||
| Total NSAID excluding low-dose aspirin | .852 | .642 | ||||||||||
| Nonuser | 271 | 49.8 | 31,613 | 52.0 | Ref.‡ | Ref.‡ | ||||||
| Low | 160 | 29.4 | 17,879 | 29.4 | 1.13 | 0.93 to 1.37 | .215 | 1.08 | 0.88 to 1.32 | .466 | ||
| High | 113 | 20.8 | 11,319 | 18.6 | 1.03 | 0.83 to 1.29 | .768 | 0.96 | 0.77 to 1.21 | .737 | ||
| Regular-dose aspirin | .474 | .324 | ||||||||||
| Nonuser | 404 | 72.3 | 47,018 | 75.4 | Ref.‡ | Ref.‡ | ||||||
| Low | 82 | 14.7 | 8,090 | 13.0 | 1.14 | 0.90 to 1.45 | .272 | 1.13 | 0.89 to 1.44 | .312 | ||
| High | 73 | 13.1 | 7,281 | 11.7 | 0.89 | 0.69 to 1.15 | .368 | 0.86 | 0.66 to 1.11 | .251 | ||
| Total nonaspirin NSAID | .357 | .976 | ||||||||||
| Nonuser | 393 | 70.7 | 41,923 | 67.9 | Ref.‡ | Ref.‡ | ||||||
| Low | 118 | 21.2 | 15,095 | 24.5 | 0.98 | 0.80 to 1.20 | .849 | 0.91 | 0.73 to 1.13 | .387 | ||
| High | 45 | 8.1 | 4,696 | 7.6 | 1.20 | 0.88 to 1.64 | .247 | 1.06 | 0.77 to 1.45 | .742 | ||
| Ibuprofen | .607 | .988 | ||||||||||
| Nonuser | 447 | 79.3 | 46,858 | 75.2 | Ref.‡ | Ref.‡ | ||||||
| Low | 87 | 15.4 | 12,009 | 19.3 | 0.92 | 0.73 to 1.16 | .472 | 0.89 | 0.70 to 1.13 | .343 | ||
| High | 30 | 5.3 | 3,420 | 5.5 | 1.10 | 0.76 to 1.60 | .599 | 0.99 | 0.68 to 1.44 | .972 | ||
Abbreviations: HR, hazard ratio; NSAID, nonsteroidal anti-inflammatory drug.
Low use, less than 4 days/week or less than 4 years; high use, at least 4 days/week and at least 4 years.
All models except for low-dose aspirin adjusted for age, sex, race/ethnicity, education, smoking, self-reported health, history of rheumatoid arthritis, history of nonrheumatoid arthritis or chronic neck/back/joint pain, history of migraines or frequent headaches, history of fatigue/lack of energy, and family history of leukemia/lymphoma. Model for low-dose aspirin adjusted for age, sex, race/ethnicity, education, smoking, self-reported health, history of coronary artery disease, diabetes, stroke, use of antihypertensive or cholesterol-lowering medications, history of fatigue/lack of energy, and family history of leukemia/lymphoma.
Reference value of 1.00.