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. Author manuscript; available in PMC: 2011 Jun 3.
Published in final edited form as: Nat Med. 2010 May 30;16(6):694–700. doi: 10.1038/nm.2160

Figure 5.

Figure 5

5-HT2 receptor inverse agonist blocks spasms in spinal cord injured humans. (a) Leg spasm triggered by brief electrical stimulation of the medial arch of the foot (3–5×T). TA, tibialis anterior. (b) Spasm recorded with tibialis anterior muscle surface EMG and quantified over the time windows indicated (LLR and SLR), before and 2 h after blocking constitutively active 5-HT2 receptors with cyproheptadine (8 mg administered orally). The inset on a different scale shows SLR. (c) Gradual reduction in the spasms (LLRs), but not SLRs, over time after inverse agonist application. (d,e) Normalized group means for LLRs (d) and SLRs (e) with cyproheptadine (n = 7 subjects). **P < 0.01 relative to control, 100%. Error bars represent s.e.m.