Table 3.
Microbial reduction (log10 CFU/mL) by time point
| Sample | Microorganism | Inoculum | 0 hours | 6 hours | 24 hours | 7 days | 14 days | 28 days |
|---|---|---|---|---|---|---|---|---|
| Latanoprost 0.005% (Lot No: LA54019) | S. aureus | 5.8 | > 4.8 | > 4.8 | > 4.8 | > 4.8 | > 4.8 | > 4.8 |
| P. aeruginosa | 5.7 | 4.7 | > 4.7 | > 4.7 | > 4.7 | > 4.7 | > 4.7 | |
| E. coli | 6.0 | > 5.0 | > 5.0 | > 5.0 | > 5.0 | > 5.0 | > 5.0 | |
| C. albicans | 5.7 | 0.9 | > 4.7 | > 4.7 | > 4.7 | > 4.7 | > 4.7 | |
| A. brasiliensis | 5.4 | 0.1 | > 4.4 | > 4.7 | > 4.4 | > 4.4 | > 4.4 | |
| Travoprost 0.004% (Lot No: 158568F) | S. aureus | 5.8 | 0 | 0.1 | 0.2 | > 4.8 | > 4.8 | > 4.8 |
| P. aeruginosa | 5.7 | 0.1 | 0.8 | 1.7 | > 4.7 | > 4.7 | > 4.7 | |
| E. coli | 6.0 | 0.3 | 1.5 | 2.8 | > 5.0 | > 5.0 | > 5.0 | |
| C. albicans | 5.7 | 0.1 | 0.2 | 0.1 | 0.6 | 1.0 | 1.8 | |
| A. brasiliensis | 5.4 | 0.1 | 0.2 | 0.9 | 1.7 | 1.9 | 1.8 |
CFU: colony-forming unit.
Latanoprost ophthalmic solution 0.005% contains 0.02% benzalkonium chloride and travoprost ophthalmic solution 0.004% contains sofZia as preservatives.
Shading indicates results not meeting European Pharmacopoeia-A (EP-A) requirements [11] (note that while testing of E. coli is required only for non-oral products in the EP, this would be considered a failing result).