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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Clin Cancer Res. 2011 Apr 19;17(11):3579–3589. doi: 10.1158/1078-0432.CCR-11-0044

Figure 4.

Figure 4

Methylation varies with the presence of local structural elements. LINE-1-discordantly methylated loci are enriched for (A) proximity to transcription factor binding sites and (B) CpG islands. Tumor data (for 61 oral/pharyngeal and 15 laryngeal tumors) are stratified by site and the distributions of loci, based on the Spearman correlations between CpG methylation and LINE-1 methylation, are plotted according to their respective kernel density estimations. GSEA permutation test p-values indicated in bold represent significant relationships (p<0.05). Dotted lines indicate the distribution of loci located within the sequence element, while solid lines indicate the distribution of loci located outside of the sequence element.