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. Author manuscript; available in PMC: 2012 Jul 15.
Published in final edited form as: Toxicol Appl Pharmacol. 2011 Feb 15;254(2):65–71. doi: 10.1016/j.taap.2010.03.023

Fig. 1.

Fig. 1

Effect of acute Mn treatment on TH activity in differentiated N27 cells. Differentiated N27 cells were incubated with 3 or 10 μM MnCl2 for 3 h with or without 3 μM rottlerin. For measurement of TH activity, cells were exposed to 2 mM NSD-1015 for 1 h prior to MnCl2 treatment. Cells were lysed after treatment and extracts were used for determining L-DOPA levels by HPLC. A, Data are presented as pg DOPA/μg protein; B, data are presented as percentage of control. The data represent a mean + SEM of six to eight individual measurements. Asterisks (*p<0.05) indicate significant differences between Mn treated cells and control cells.