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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Clin Cancer Res. 2011 Apr 11;17(11):3706–3715. doi: 10.1158/1078-0432.CCR-10-3082

Figure 6. pS345 Chk1 induction occurs independent of PP2A and correlates with increased DNA damage response.

Figure 6

MiaPaCa-2 cells were treated according to Schedule 2 (Fig. 1A). At t = 24 hours cells were treated with AZD7762 and/or okadaic acid (OA, 1uM) for 1 hour. At the end of treatment, cells were prepared for immunoblotting (A, B) or FACS analysis (C). Data are from a single experiment (A) or are the mean of 3 – 4 independent experiments (B–C). Statistically significant differences (P<0.05) were determined by a paired t-test comparing control versus 7762*, Gem versus Gem 7762‡, OA versus 7762 OA or Gem OA†, versus Gem 7762 OAπ.