Table 1.
Patient Demographic and Disease Characteristics.
| Characteristics | Schedule A (Daily×5 schedule) |
Schedule B (Daily×3 schedule) |
||
|---|---|---|---|---|
| Number of patients enrolled | 7 | 17* | ||
| Age (Years) | ||||
| Median | 46 | 59 | ||
| Range | 23–75 | 40–84 | ||
| Gender | ||||
| Male | 5 | 9 | ||
| Female | 2 | 8 | ||
| Race | ||||
| Caucasian | 6 | 15 | ||
| African American | 1 | 2 | ||
| ECOG | ||||
| PS=0 | 2 | 4 | ||
| PS=1 | 5 | 13 | ||
| Number of prior chemotherapy regimens | ||||
| Median | 3 | 3 | ||
| Range | 1–5 | 1–6 | ||
| Primary tumor site | Colon | 3 | Colon | 5 |
| Anaplastic thyroid | 1 | Bladder | 2 | |
| Melanoma | 1 | Head & neck | 2 | |
| Osteosarcoma | 1 | NSCLC | 1 | |
| Prostate | 1 | SCLC | 1 | |
| Ovarian | 1 | |||
| Paraganglioma | 1 | |||
| Gastric | 1 | |||
| Leiomyosarcoma | 1 | |||
| Osteosarcoma | 1 | |||
| Unknown primary | 1 | |||
*
Of the 17 patients enrolled on the daily × 3 schedule, 14 patients were evaluable and three were taken off the study at or prior to completion of cycle 1.