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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Cancer Prev Res (Phila). 2011 Mar 16;4(6):879–889. doi: 10.1158/1940-6207.CAPR-11-0025

Figure 6.

Figure 6

RLIP76: A multi-specific regulator of multi-drug resistance and tumor-progression: RLIP76 transports the GS-E of lipid-peroxidation products and administered chemotherapy drugs out of cells, thereby reducing the cytotoxic impact of both radiotherapy and chemotherapy. In addition, RLIP76 regulates vital proliferative and metastatic signaling networks in cancer cells (Arrows: green-stimulation, red-inhibition, blue-transport and yellow-interaction). RLIP76 by its interaction with AP2 regulates the EGFR endocytosis. RLIP76 binds with CDK1 and translocates where it participates in the spindle formation during mitosis. RLIP76 is a critical mediator of PKCα-induced proliferation and drug resistance. RLIP76 enhances the migration of cells by activating GTPase R-Ras and Rac.