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P53 mutations and drug-resistance in neuroblastoma cell lines
| Status of p53 | Cell line | p53 Mutation |
IC50 (μM) | |
|---|---|---|---|---|
| DOX | CDDP | |||
| Mutated | CHLA90 | E286K | 0.60 ± 0.1 | 30 ± 4 |
| SK-N-BE(2) | C135F | 0.88 ± 0.1 | 22 ± 2 | |
| Wild-type | SMS-KCNR | 0.02 ± 0.0 | 4 ± 1 | |
| LA –N-5 | 0.02 ± 0.0 | 10 ± 1 | ||
Drug-sensitivity assays were performed using MTT to determine IC50 values. The values are presented as mean ± SD from three separate determinations with eight replicates each (n = 24)
