Table 9.

The correlation of MGMT/hMLH1 promoter methylation with the immunoreaction of the corresponding proteins in all cancers, serrated cancers and their matched controls

			MGMT expression*				hMLH1 expression
	Promoter methylation of MGMT/hMLH1	All, N	Positive	Negative	P-value (Fisher's exact test)	All, N	Positive	Negative	P-value (Fisher's exact test)
All cases	Unmethylated	45	45	0	<0.0001	52	48	4	0.086
	Unmethylated and methylated	27	21	6		25	21	4
	Methylated	11	5	6		5	3	2
Serrated CRC	Unmethylated	13	13	0	0.041	13	12	1	0.186
	Unmethylated and methylated	17	13	4		14	11	3
	Methylated	4	2	2		4	2	2
Matched controls	Unmethylated	16	16	0	0.013	24	21	3	0.553
	Unmethylated and methylated	6	4	2		4	3	1
	Methylated	6	3	3		1	1	0

For *MGMT immunoreaction, tumour tissue presenting over 10% of positive cells was considered to be positive.

CRC, Colorectal carcinoma.