Table 2a.

Association between cumulative sun-damage score (CSD) and BRAF mutation stratified by anatomic site.

	BRAF mutation (%)
	CSD 0-3	CSD 4-6	CSD 7-10	p-value*
European and North American melanomas
Face or scalp (n=74)	100% 4 of 4	31% 4 of 13	18% 10 of 57	P=0.002
Upper extremities (n=51)	64% 9 of 14	33% 7 of 21	13% 2 of 16	P=0.004
Trunk (n=200)	68% 62 of 91	57% 56 of 99	50% 5 of 10	P=0.08
Lower extremities (n=99)	61% 23 of 38	53% 28 of 53	50% 4 of 8	P=0.51
Australian melanomas
Face or scalp (n=62)	0% 0 of 2	32% 6 of 19	24% 10 of 41	P=1.0
Trunk (n=58)	88% 7 of 8	51% 19 of 37	39% 5 of 13	P=0.048

^*p-value of exact Chi-square test for trend.