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Structure of the active site of cytosine deaminase. (A) Fe-CDA in the absence of bound ligands. The coordinates were taken from PDB code: 1K6W. The three residues that facilitate the nucleophilic attack of water (Glu-217, His-246, and Asp-313) and the residue that facilitates the binding of cytosine (Gln-156) are shown. (B) The active site of Zn-CDA in the presence of the tight-binding transition state inhibitor phosphonocytosine (PDB code: 3O7U).
