Table 2.
Detection of HLA Ab screen reactive donorsa if HLA Ab testing were restricted to females based on various pregnancy histories.
| Screening Cutoff | Total # of LAPS Donors Positive for Any HLA Ab | All Females | Ever Pregnant | 2+ Pregnancies | 3+ Pregnancies | 4+ Pregnancies |
|---|---|---|---|---|---|---|
| n | n (%) of all screen positive LAPS Donors with any HLA antibodies using a 3SD cutoffb2 | |||||
| >3SD | 1033 | 1006 (97.4%) | 973 (94.2%) | 902 (87.3%) | 611 (59.1%) | 320 (31.0%) |
| >4SD | 748 | 735 (71.2%) | 723 (70.0%) | 677 (65.5%) | 463 (44.8%) | 240 (23.2%) |
| >5SD | 482 | 476 (46.1%) | 469 (45.4%) | 442 (42.8%) | 299 (28.9%) | 152 (14.7%) |
a
HLA Ab screen reactivity was defined as having NBG values greater than the 3SD cutoffs on the Luminex LabScreen Mixed assay.
b
Denominator = Total # of LAPS donors screen positive for any HLA Ab using 3SD cutoffs as the definition of screen positive (n=1033). Samples were from individual donations from unique donors.