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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: J Neurochem. 2011 Mar 7;118(5):826–840. doi: 10.1111/j.1471-4159.2011.07210.x

Figure 7. Neuronal death induced by astrocytes is prevented by Panx1 hemichannel blockers but not by connexin hemichannel blockers; protection by P2X and NMDA receptor blockers.

Figure 7

Averaged Etd uptake (white bars) and death (black bars) normalized to control of neurons treated for 1 h with CM-Ast alone or after 20 min pretreatment and continued application of 20 μM CPP (NMDA receptor blocker), 300 μM oATP (P2X receptor blocker), 200 μM suramin (P2 receptor blocker), 10 μM BBG (P2X7 receptor blocker) or 10 U/ml apyrase (ATPase). It is shown the effect of probenecid (Prob) and 10panx1 in the abovementioned responses. Prob and 10panx1 were applied at 200 μM during reoxygenation. *p < 0.001, compared to Ast-CM effect. Each value corresponds to mean ± S.E. of at least 4 independent experiments.