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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: J Neurochem. 2011 Mar 7;118(5):826–840. doi: 10.1111/j.1471-4159.2011.07210.x

Figure 8. Aβ25-35-treated microglia increase the release glutamate and ATP from astroglial Cx43 hemichannels during reoxygenation.

Figure 8

Release of glutamate (black bars) and ATP (gray bars) by astrocytes under control conditions or treated with CM-Aβ for 24 h and then subjected to 3 h hypoxia in 5 mM glucose followed by 1 h reoxygenation. In some experiments 200 μM Gap26, 500 μM probenecid (Prob), 200 μM 10panx1 and 10 μM brefeldin A (Bref A) were applied during the reoxygenation period. Also is shown data from astrocytes from Cx43−/− mice subjected to the same abovementioned protocols.