Table 3.
Characteristics of samples for the in situ hybridization and microarray analyses.
| Study | Disease status (n) | Mean age at death, years (range) | Mean PMI1, hours (range) | Mean RIN2 (range) | Tissue pH (range) |
|---|---|---|---|---|---|
| In situ hybridization | Control (20) | 71.35 (40–106) | 9.38 (1.50–28.17) | 7.40 (6.40–8.10)* | 6.78 (6.29–7.32) |
|
| |||||
| PD (19) | 77.89 (66–89) | 9.71 (1.16–30.75) | 7.20 (5.60–8.40)* | 6.56 (5.88–6.84) | |
|
| |||||
| t-test p-value+ | 0.140 | 0.916 | 0.614 | 0.030 | |
|
| |||||
| Microarray | Control (29) | 75.21 (58–97) | 13.70 (1.50–39.67) | 7.36 (4.8–8.5) | 6.64 (6.26–7.32) |
| PD (33) | 77.67 (64–94) | 7.43 (1.16–30.75) | 7.182 (5.2–8.4) | 6.65 (6.27–7.13) | |
| t-test p-value+ | 0.335 | 0.010 | 0.438 | 0.842 | |
1
PMI: post-mortem interval
2
RIN: RNA Integrity Number
*
RIN available only for samples present in the microarray study
+
t-test between PD and control values