. Author manuscript; available in PMC: 2011 Oct 1.

Published in final edited form as: Pulm Pharmacol Ther. 2010 Feb 23;23(5):456–464. doi: 10.1016/j.pupt.2010.02.003

Table 1.

Effect of sildenafil, simvastatin and combination therapy on plasma NO, cGMP, BNP, t-PA, PAI-1, MMP-2, and MMP-9 concentrations (each group, n=8)^# in rats injected with MCT.

Molecules	Sham-treated	MCT-Control	Sildenafil	Simvastatin	Combination
NO (μmol/L)	39.51±9.22	18.89±3.87	30.45±7.55^**	27.34±7.71^*	31.28±6.08^**
cGMP (pmol/ml)	12.19±4.76	3.08±1.71	9.22±4.63^**⁺	8.42±4.77^*⁺	10.64±4.77^**
BNP (ng/ml)	13.13±2.47	33.78±4.91	22.62±2.96^**⁺	22.71±2.86^*⁺	17.87±2.84^**
t-PA (ng/ml)	0.56±0.13	1.74±0.79	1.06±0.46^**	1.11±0.54^*	1.09±0.29^*
PAI-1 (ng/ml)	0.21±0.04	0.71±0.30	0.31±0.13^**	0.23±0.04^**	0.22±0.04^**
MMP2 (ng/ml)	9.96±2.82	15.82±4.24	13.99±1.34⁺	12.49±1.08^*	10.75±1.29^**
MMP9 (ng/ml)	79.75±21.86	172.25±33.16	108.63±36.05^**	103.13±29.19^*	88.13±28.82^**

Data are presented as mean ± SD; Sham-treated, rats injected with vehicle;

MCT-Control, rats injected with MCT; Sildenafil, MCT-injected rats treated with sildenafil alone; Simvastatin, MCT-injected rats treated with simvastatin alone; Combination, MCT-injected rats treated with sildenafil and simvastatin.

P<0.05,

^**

P<0.01 vs. MCT-Control group;

⁺

P<0.05 vs. Combination group.

Additionally, all MCT-Control group values were found to be significantly different from the Sham-treated group values.