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. Author manuscript; available in PMC: 2011 Jun 6.
Published in final edited form as: Proc IEEE Int Symp Bioinformatics Bioeng. 2010:99–105. doi: 10.1109/BIBE.2010.24

Figure 5.

Figure 5

A flow diagram of the APACE phylogenetic profile clustering method. The normalization factor, rj, is ultimately computed to be the multiplicand that equalizes the average similarity scores of every widely-conserved protein in P* to each reference proteome Pj and is initiated as 1. W* is the set of most conserved in P* and is by construction a strict subset of P*. The value of C is the arbitrary constant evolutionary distance every Pj is normalized to from P* through each rj.