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Stabilins, novel endothelial scavenger receptors, could have a role in the clearance of OxLDL in the liver and from circulation. Heavily oxidized LDL is taken up by Kupffer cells, whereas sinusoidal endothelial cells can take up both mildly and highly oxidized form of LDL. The novel scavenger receptors stabilin-1 and -2, which can bind to both types of OxLDL, could be involved in the process of clearing OxLDL from the circulation in the liver.
